Katja Heinicke1,2, Ivan Dimitrov3,4,
Jimin Ren3, Deborah Douglas3, Andrew G. Webb5,
Craig R. Malloy3, Ronald G. Haller1,2
1Neuromuscular Center, Institute for
Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas,
TX, United States; 2Department of Neurology, University of Texas
Southwestern Medical Center, Dallas, TX, United States; 3Advanced
Imaging Research Center, University of Texas Southwestern Medical Center,
Dallas, TX, United States; 4Philips Medical Systems, Cleveland,
OH, United States; 5Department of Radiology, dC.J. Gorter High
Field Magnetic
1H-magnetic
resonance spectroscopy (1H-MRS) can be used to noninvasively determine oxygen
tension in human skeletal muscle. The purpose of this pilot study was to
investigate the feasibility to detect the deoxy-Mb signal in skeletal muscle
using 1H-MRS in ultra-high fields (7 Tesla). Spectra were acquired on a
whole-body 7T scanner using a single-loop linear T/R surface coil with 10-cm
diameter. Deoxy-Mb signal was observed in calf muscle in three healthy
subjects during ischemia with 160-240 mmHg cuff pressure applied above the
knee. The study demonstrates the feasibility of measuring deoxy-Mb in
skeletal muscle using 1H-MRS at 7T.
Keywords