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Abstract #0923

A Metabonomic Analysis of Serum from Wilsons Disease Rats Using 1H NMR Spectroscopy and Pattern Recognition

Yangyang Wei1, Huaizhou Jiang2, Jingjing Xu1, Jiyang Dong1, Shuhui Cai1, Zhong Chen1

1Department of Physics, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian, China; 2Hubei University of Traditional Chinese Medicine, Wuhan, Hubei, China

The biochemical variations of serum from control and Wilsons disease (WD) rats were investigated using NMR-based metabolomics. Two groups can be discriminated according to the score plot of principle component analysis. The WD group shows increased levels of lactate, glycoprotein, glutamine, creatine, creatininearginine and decreased levels of glucose, trimethylamine-N-oxide, betaine, lipid and choline. The results may further our understanding of the disease.