Najib Allali1,2, Malgorzata Marjanska3,
Edward J. Auerbach3, Eric Bardinet1, Philippe Fossati4,
Romain Valabrgue1, Stphane Lehricy1
1CRICM (CENIR), UPMC/INSERM UMRS 975/
CNRS UMR 7225, Hpital Piti-Salptrire, Paris, France; 2Centre
Emotion CNRS USR 3246, Paris, France; 3Center for Magnetic
Resonance Research and Department of Radiology, University of Minnesota,
Minneapolis, MN, United States; 4Centre Emotion CNRS USR 3246,
Hpital Piti-Salptrire, 47 bd de l'Hpital 75013 Paris, France
Scan
to scan reproducibility is challenging, especially in the deep brain regions
such as hippocampus where lower SNR and poor magnetic field homogeneity can
lead to larger uncertainties in metabolite quantification. Few studies have
investigated 1H-MRS reproducibility in the hippocampus either at low magnetic
field strength or with few subjects.
Relatively large VOI were used in most of these studies, resulting in
partial volume effects. In this study,
we investigated the reproducibility of spectroscopic measurements in the
hippocampus at 3 tesla using a LASER sequence . We performed our measurements
in a 2.4 mL volume to minimize partial volume effects.
Keywords