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Abstract #0940

Simultaneously Assessed GABA/Glutamate/Glutamine Concentration Gender Differences at 3.0T

Peter Sheffield1,2, Michael D. Noseworthy, 2,3

1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada; 2Brain-Body Institute, St. Joseph's Healthcare, Hamilton, ON, Canada; 3Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada

Herein we demonstrate the necessity for separating control subjects by gender when analyzing the metabolites of the GABA/glutamate/glutamine (Glx) spin system. Seven male and five female subjects were recruited to assess differences in these metabolites using a STEAM sequence optimized for Glx quantification. Results indicate that GABA concentrations in the anterior cingulate cortex of females are significantly lower than in males, in contrast to previous occipital GABA studies. Therefore, care must be taken when developing control groups for Glx metabolite analysis. Our results also illuminate a possible etiology for executive mood disorder obscured by previous reports.