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Abstract #0980

Initial Experience with 31P Imaging of Human Brain Using a Multi-Resonance, Spectral-Selective Sequence at 9.4Tesla

Aiming Lu1, Ian C. Atkinson1, Xiaohong Joe Zhou1,2, Keith R. Thulborn1

1Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States; 2Departments of Neurosurgery, Radiology, and Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Phosphocreatine (PCr) concentration can provide vital bioenergetic information in brain. Due to their low detection sensitivity, 31P MR signals are often detected with MRS or CSI approaches, which are either time consuming or spatial resolution limited. In this work, we report initial 31P imaging results using a spectral selective twisted projection imaging (TPI) sequence to achieve high data acquisition efficiency on a 9.4T human scanner. PCr and γ-ATP images were simultaneously obtained with whole brain coverage and reasonable SNR, temporal and spatial resolution. The ratio of the two resonances images can potentially allow detection of variation in PCr concentration.