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Abstract #0981

In Vivo Chlorine-35, Sodium-23 and Proton Magnetic Resonance Imaging of the Rat Brain

Stefan Kirsch1, Mark Augath2, David Seiffge3, Lothar Schilling3, Lothar Rudi Schad1

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; 2Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany; 3Division of Neurosurgical Research, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

In this study we demonstrate the feasibility of combined chlorine-35, sodium-23 and proton magnetic resonance imaging (MRI) at 9.4 Tesla and, to the best of our knowledge, present the first in vivo chlorine-35 images obtained by means of MRI. With the experimental setup all measurements could be done in one session without changing the setup or moving the subject. Multinuclear MR images were acquired from a healthy rat and from a rat displaying a focal cerebral infarction. Combined in vivo chlorine-35, sodium-23 and proton MRI may provide a new approach to study diseases which involve changes in the concentration of chloride or sodium ions.