Stefan
Kirsch1, Mark Augath2, David Seiffge3,
Lothar Schilling3, Lothar Rudi Schad1
1Computer Assisted Clinical Medicine,
Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; 2Department
of Physiology of Cognitive Processes, Max Planck Institute for Biological
Cybernetics, Tuebingen, Germany; 3Division of Neurosurgical
Research, Medical Faculty Mannheim, University of Heidelberg, Mannheim,
Germany
In
this study we demonstrate the feasibility of combined chlorine-35, sodium-23
and proton magnetic resonance imaging (MRI) at 9.4 Tesla and, to the best of
our knowledge, present the first in
vivo chlorine-35 images obtained by means of MRI. With the experimental
setup all measurements could be done in one session without changing the
setup or moving the subject. Multinuclear MR images were acquired from a
healthy rat and from a rat displaying a focal cerebral infarction. Combined in vivo chlorine-35, sodium-23 and
proton MRI may provide a new approach to study diseases which involve changes
in the concentration of chloride or sodium ions.
Keywords