Sandro Romanzetti1, Eberhard D. Pracht1, N. Jon Shah1,2
1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Juelich, Juelich, Germany; 2Faculty of Medicine, Department of Neurology, RWTH Aachen, Aachen, Germany
Imaging of nuclei such as 23Na, 31P, and 17O is becoming very important to understand the physiology of the cell. However, due to the low concentration and short relaxation times of theses nuclei in tissues, dedicated sequences and high optimisation are required. The SPRITE sequence has shown its ability to image the sodium in the in vivo human brain at ultrashort encoding times. In this work, a novel way to improve the sensitivity of the standard SPRITE sequence by a factor 2 is presented. This is of particular relevance for all applications where the SNR is very low.