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Abstract #0987

Oxygen Partial Pressure and Uptake Rate in the Lung with Hyperpolarized 129Xe MRI: Preliminary Results

Mikayel Dabaghyan1, Isabel Maria Dregely2, Iga Muradyan1, Mirko I. Hrovat3, Hiroto Hatabu1, James P. Butler4, Samuel Patz1

1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Department of Physics, University of New Hampshire, Durham, NH, United States; 3Mirtech, Inc, Brockton, MA, United States; 4Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States

In this study we measured the regional partial pressure of oxygen in human lungs, using hyperpolarized xenon, whose signal depends on the presence of oxygens paramagnetic molecules. Similar studies have been conducted in the past using HP helium. A number of images was acquired and the evolution of the signal in each pixel was fit to a model describing its decay with time, taking into account the longitudinal relaxation time (T1), which is affected by the partial pressure of oxygen. Other parameters obtained from fitting the data to the model were the oxygen uptake rate RO2 and the flip angle for each pixel.