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Abstract #0999

In Vivo Multicolor Imaging of Perfluorocarbon Emulsions Using Ultrafast Spectroscopic Imaging (F-UTSI)

Muhammed Yildirim1,2, Shelton D. Caruthers3, Aart J. Nederveen4, Jaap Stoker4, Rolf Lamerichs1

1Philips Research, Eindhoven, Netherlands; 2Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 3Washington University, St Louis, MO, United States; 4Department of Radiology, Academic Medical Center, Amsterdam, Netherlands

In vivo 3D F-uTSI, can distinguish various 19F compounds based on chemical shift differences allowing for multicolor imaging, without additional increase in scan time. 3D F-uTSI is an efficient spectral imaging technique; data with a resolution of 48x48x14 can be recorded with a scan-time of 6:23m. The spectra of several Perfluorocarbon emulsion can be uniquely identified from these data. Main advantage of the spectroscopic, multicolor, imaging approach is that the spectral images of the different PFC agents are recorded at the same time and, furthermore, complex biological process can be imaged using co-injection of differently functionalized PFC emulsions.