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Abstract #0998

The Loss of Sodium Homeostasis and Apoptosis During Rodent Glioma Chemotherapy

Victor D. Schepkin1, Cathy W. Levenson2, Fabian F. Calixto-Bejarano2, William W. Brey1, Petr L. Gor'kov1

1CIMAR, NHMFL/FSU, Tallahassee, FL, United States; 2College of Medicine, FSU, Tallahassee, FL, United States

The goal of the present study was to assess the hypothesis that an in vivo increase of intracellular sodium is one of the first and a crucial stage during cancer therapy. Experiments were performed using high resolution sodium and diffusion MRI at 21.1T and rodent glioma model. During efficient BCNU chemotherapy, tumor sodium reaches a plateau indicating a complete loss of Na homeostasis at day 4 following the initiation of therapy. Dose dependent responses of intracellular sodium can serve as a very early biomarker for the onset of apoptosis and forecast tumor elimination.