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Abstract #0997

19F Magnetic Resonance Quantification of SiRNA Delivery Via Perfluorocarbon Nanoparticle Emulsions

Jacob Wheatley Myerson1, Megan M. Kaneda1, Gregory M. Lanza1,2, Samuel A. Wickline1,2

1Biomedical Engineering, Washington University, Saint Louis, MO, United States; 2Department of Medicine, Washington University, Saint Louis, MO, United States

Perfluorocarbon nanoparticles were functionalized to deliver VCAM-1 siRNA to human melanoma cells. Delivery was quantified via 19F magnetic resonance spectroscopy. For future in vivo studies, an MR-trackable delivery agent would aid in the determination of localization of siRNA delivery to specific tissues.