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Abstract #1016

Single-Shot Spiral Chemical Shift Imaging in the Rat In Vivo with Hyperpolarized [1-13C]-Pyruvate

Dirk Mayer1,2, Yi-Fen Yen3, Atsushi Takahashi3, James Tropp3, Brian K. Rutt2, Ralph E. Hurd3, Daniel M. Spielman2, Adolf Pfefferbaum1,4

1Neuroscience Program, SRI International, Menlo Park, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3GE Healthcare, Menlo Park, CA; 4Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

Using undersampled 13C spiral chemical shift imaging (CSI) in combination with a high-performance gradient insert we achieved single-shot hyperpolarized 13C metabolic imaging of the rat in a clinical 3T MR scanner. With an acquisition time of 125 ms, the method produced metabolic images of pyruvate and its metabolic products lactate and alanine with similar quality as with conventional CSI using phase encoding, despite an almost 200-fold reduction in acquisition time. Because the longitudinal magnetization does not recover in hyperpolarized MRI, there is no intrinsic SNR disadvantage of the faster imaging method.