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Abstract #1018

In Vivo Detection of Radiation-Induced Metabolic Response in Rat Kidneys by 13C Hyperpolarized MRSI

Lasitha Senadheera1, Dirk Mayer2,3, Moses Darpolor2, Yi-Fen Yen4, Lei Xing1, Daniel Spielman2

1Radiation Oncology, Stanford University, Stanford, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Neuroscience Program, SRI International, Menlo Park, CA, United States; 4Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

Radiation dose to the tumors is often limited by the irradiation of adjacent organs at risk, such as kidneys. Unlike structural change, metabolic response may reflect early signs of radiation damage in tissues, offering opportunity to better design radiotherapy. Following hyperpolarized [1-13C]pyruvate injection, 13C MRSI was employed to detect radiation-induced metabolic response in rat kidneys at various radiation doses and postirradiation times. No trend in Lactate/pyruvate ratios was observed between irradiated and normal kidneys of the same animal. Metabolic response of irradiated kidneys might not be strong enough to become visible in 13C MRSI, within our experimental errors and conditions.