Dirk Mayer1,2, Yi-Fen Yen3, Atsushi
Takahashi3, Sonal Josan1,2, James Tropp3,
Adolf Pfefferbaum1,4, Ralph E. Hurd3, Daniel M.
Spielman2
1Neuroscience Program, SRI
International, Menlo Park, CA, United States; 2Radiology, Stanford
University, Stanford, CA, United States; 3GE Healthcare, Menlo
Park, CA; 4Psychiatry and Behavioral Sciences, Stanford
University, Stanford, CA, United States
Time-resolved
spiral chemical shift imaging was applied to investigate the uptake dynamics
in the anesthetized rat brain after injection of hyperpolarized [1-13C]-pyruvate.
Additionally, metabolic imaging at high spatial resolution was performed to
better characterize the spatial origin of the metabolite signals. Higher
lactate (Lac) and bicarbonate (Bic) signals were found in cortical regions of
the brain. This could be due to higher flux of Pyr through the blood-brain
barrier, faster substrate-to-product conversion, or both. Metabolite time
courses from a region-of-interest in the cortex suggest slower production of
Bic compared to Lac.
Keywords