Francesca
Frijia1, Luca Menichetti1, Vincenzo Positano1,
Vincenzo Lionetti2, Claudia Forte3, Jan H.
Ardenkjaer-Larsen4, Matteo Milanesi1, Giulio
Giovannetti1, Daniele De Marchi1, Giovanni Aquaro1,
Manuela Campan2, Fabio A. Recchia5, Luigi Landini1,
Maria Filomena Santarelli1, Massimo Lombardi1
1MRI Lab, "G. Monasterio"
Foundation and Institute of Clinical Physiology, P
Changes
in metabolic products of pyruvate can be correlated to the
patho-physiological condition of the myocardium: The cardiac oxidation of
pyruvate depends on oxygen delivery to myocardium and on the activation state
of mitochondrial pyruvate dehydrogenase. The real time tracking of the
metabolic fate of pyruvate in the intact heart with MRS would provide a key
information on the state of myocardium in response to a variety of stimuli.
This study deal with the real time in vivo cardiac metabolism after
intravenous injection of hyperpolarized [1-13C]-pyruvate in the animal of mid
size with a 3T scanner with regards to the typical kinetic profile of
accumulation of each metabolite and if the typical pattern could be modelled
with simple equations.