Meeting Banner
Abstract #1024

Modeling of Pyruvate/Lactate Kinetics Using a Two-Site Exchange Model

Aaron Keith Grant1, Elena Vinogradov1, Pankaj K. Seth1, Xiaoen Wang1, Robert E. Lenkinski1, Vikas P. Sukhatme1

1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Hyperpolarized pyruvate undergoes rapid conversion into lactate, alanine, and bicarbonate in vivo. Lactate is of particular interest as elevated lactate levels may serve as a biomarker for cancer. Although lactate SNR has been shown to correlate with histological characteristics of tumors, quantitative measures of kinetics are desirable. We present fits of a simple two-site exchange model to data acquired in an animal model of non-small lung cancer, and show that these methods can quantify reductions in lactate formation rates following administration of dichloroacetate, a drug that up-regulates the activity of pyruvate dehydrogenase.