Matthew E. Merritt1,2, M Mishovsky3,4,
T. Cheng3, Ashish Jindal5, Zoltan Kovacs5,
Craig Malloy5,6, Rolf Gruetter3,7, A Dean Sherry5,8,
Arnaud Comment3,9
1Advance Imaging Research Center, UT
Southwestern Med. Center, Dallas, TX, United States; 2Radiology,
UTSW Medical Center, Dallas, TX, United States; 3Laboratory for
Functional and Metabolic Imaging, Ecole Polytechnique Federal de Lausanne,
Lausanne, Switzerland; 4Radiology, Universite de Lausanne,
Lausanne, Switzerland; 5AIRC, UTSW Medical Center, Dallas, TX,
United States; 6Cardiology, North Texas VA Hospital, Dallas, TX, United
States; 7Radiology, Universite de Geneve, Geneva, Switzerland; 8Chemistry,
University of Texas at Dallas, Richardson, TX, United States; 9Institute
of Condensed Matter Physics , Ecole Polytechnique Federal de Lausanne,
Lausanne, Switzerland
In vivo 89Y MRS of a
rat kidney was performed in a 9.4 T animal scanner after infusion of
hyperpolarized 89Y(DOTA) -. The hyperpolarized solution
was prepared by dynamically polarizing the 89Y nuclear spins of
the Y3+ complexes at 5 T and 1.05 K using the TEMPO free radical.
The rapid injection of the solution led to subsequent large in vivo 89Y signal detected
in the rat kidney. It was observed that the decay time of the signal is long
enough to perform hyperpolarized 89Y in vivo studies.
Keywords