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Abstract #1037

Characterization of Tumor Microvascular Structure and Permeability by MRI and Intravital Confocal Imaging

Nina Kristine Reitan1, Marte Thuen2, Pl Erik Goa3

1Department of Physics, NTNU, Trondheim, Norway; 2Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway; 3Department of Radiology, St. Olavs Hospital, Trondheim, Norway

By using confocal laser scanning microscopy (CLSM) and MRI we studied microvascular architecture and permeability in tumors growing in dorsal window chambers in mice. 40 kDa dextran and Gadomer was used as molecular tracers for dynamic CLSM and DCE-MRI, respectively. Correlation was found between permeability measured by the two techniques and permeability further depended on structural parameters, like fractal dimension and vascular density. This study demonstrates that the dorsal window tumor model gives an opportunity to use CLSM and MRI as supplementary techniques and that CLSM provides insight into the spatial heterogeneous microenvironment on a microscopic level that is not accessible with MRI.