Meeting Banner
Abstract #1063

Repeated Resting State FMRI During Dose-Controlled Morphine and Alcohol Infusion Reveals Localized and Drug Specific Changes in Functional Brain Connectivity

Najmeh Khalili-Mahani1,2, Remco W. M Zoethout3, Christian F. Beckmann4,5, Evelinda Baerends6, Roelof P. Soeter, 2,6, Marike de Kam3, Mark A. Van Buchem6, Joop M. A. Van Gerven3, Serge A. R .B. Rombouts, 2,6

1Leiden University Medical Center, Department of Radiology, Leiden , Netherlands; 2Leiden Institute for Brain and Cognition, Department of Psychology, Leiden, Netherlands; 3Center for Human Drug Research, Leiden University Medical Center, Leiden, Netherlands; 4Oxford University, Oxford, United Kingdom; 5Imperial College London, London, United Kingdom; 6Leiden University Medical Center, Department of Radiology, Leiden, Netherlands

Using state of art pharmacological infusion techniques in a placebo-controlled two-way (treatment by time: 3x7) repeated measure study we show specific and meaningful variations in resting-state brain connectivity in response to dose-controlled administration of morphine and alcohol