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Abstract #1064

Focal and Drug-Specific Changes in Cerebral Blood Flow in Response to Dose-Controlled Infusion of Alcohol and Morphine in Healthy Young Men

Najmeh Khalili-Mahani1,2, Mathiass J. P. Van Osch1, Remco W. M Zoethout3, Evelinda Baerends1, Mark A. Van Buchem1, Joop M. A. Van Gerven3, Serge A. R. B. Rombouts1,2

1Leiden University Medical Center, Department of Radiology, Leiden, Netherlands; 2Leiden Institute for Brain and Cognition, Department of Psychology, Leiden, Netherlands; 3Center for Human Drug Research, Leiden University Medical Center, Leiden, Netherlands

In a within-subject placebo-controlled pharma-fMRI study, we use pseudo-continuous ASL to show localized and drug-specific changes in CBF in response to dose-controlled infusion of morphine and alcohol. Results correspond to variations observed in the resting-state BOLD fluctuations in the same study.