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Abstract #1065

Levo-Tetrahydropalmatine Treatment Attenuates Heroin-Priming Induced BOLD Responses in Heroin-Dependent Rats

Xiping Liu1, Zheng Yang2, Jun Xie3, Qian Yin1, Shi-Jiang Li1

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Beijing Institute of Basic Medical Science, China; 3GE Healthcare, United States

Levo-tetrahydropalmatine (l-THP), purified from the Chinese herb, Stephanie, recently has been demonstrated to be effective in attenuating heroin craving and relapse in heroin addicts; it also inhibits cocaines rewarding effects on animal models. Despite this behavioral evidence, the treatment mechanisms of l-THP for drug addiction have yet to be elucidated. Here, we applied high-field pharmacological MRI (phMRI) on heroin-dependent rats with or without chronic l-THP treatment. We found l-THP significantly attenuates heroin-priming induced BOLD responses in heroin-dependent rats in multiple addiction relevant neural circuitries.