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Abstract #1070

Influence of Drug Substances with Different Solubility on Hydration Processes of Prolonged Release Tablets

Anna Mlynarczyk1, Marco Gruwel2, Piotr Kulinowski1, Krzysztof Jasinski1, Przemyslaw Dorozynski3, Boguslaw Tomanek, 12, Wladyslaw P. Weglarz1

1Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland; 2Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada; 3Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University, Krakow, Poland

MR microscopy was applied for study of water mobility and concentration in tablets, used for drug delivery. The tablets made of Hydroxypropylmethylcellulose-HPMC with and without addition of a drug substance of different solubility (L-dopa and ketoprofen) were tested. Two-dimensional T2 and proton density (PD) maps and their histograms were obtained. Spatial T2 and PD distributions along a tablet radius were also analyzed. Different mechanisms of tablets hydration were observed due to composition of the formulations, eg. for formulation with ketoprofen (low solubility of 0,24 mg/mL) the hydrogel formation was negligible.