Anna Mlynarczyk1, Marco Gruwel2,
Piotr Kulinowski1, Krzysztof Jasinski1, Przemyslaw
Dorozynski3, Boguslaw Tomanek, 12, Wladyslaw P. Weglarz1
1Department of Magnetic Resonance
Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Krakow,
Poland; 2Institute for Biodiagnostics, National Research Council
of Canada, Winnipeg, Manitoba, Canada; 3Department of
Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University,
Krakow, Poland
MR
microscopy was applied for study of water mobility and concentration in
tablets, used for drug delivery. The tablets made of
Hydroxypropylmethylcellulose-HPMC with and without addition of a drug
substance of different solubility (L-dopa and ketoprofen) were tested.
Two-dimensional T2 and proton density (PD) maps and their histograms were
obtained. Spatial T2 and PD distributions along a tablet radius were also
analyzed. Different mechanisms of tablets hydration were observed due to
composition of the formulations, eg. for formulation with ketoprofen (low
solubility of 0,24 mg/mL) the hydrogel formation was negligible.
Keywords