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Abstract #1105

Interleaved TMS/CASL: State Dependence of Repetitive TMS Effects on the Dorsal Premotor Cortex

Marius Moisa1, Rolf Pohmann1, Hartwig Roman Siebner2, Axel Thielscher1

1Max Planck Institute for Biological Cybernetics, Tbingen, BW, Germany; 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark

We have recently demonstrated the technical feasibility and the potential advantages of combining transcranial magnetic stimulation (TMS) with continuous arterial spin labeling (CASL) imaging. Here, we use this novel approach to assess the effects of repetitive TMS applied to the left dorsal premotor cortex (PMd) on rCBF (regional cerebral blood flow) during different motor states. The state-dependent effects of left PMd rTMS on rCBF, is in concordance with previous results using BOLD imaging and a different task. As a next step, we will analyze the time dependence of the observed TMS effects across the different experimental blocks of one run.