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Abstract #1127

Cerebral Blood Volume Changes in Arterial and Post-Arterial Compartments and Their Relationship with Cerebral Blood Flow Alteration During Brief Breath-Holding and Visual Stimulation in Human Brain

Jun Hua1, Robert Stevens1, Manus J. Donahue1,2, Alan J. Huang1, James J. Pekar1, Peter C.M. van Zijl1

1Department of Radiology, The Johns Hopkins University, Baltimore, MD, United States; 2Department of Clinical Neurology, Oxford University, Oxford, United Kingdom

Changes in CBF/CBV/arterial-CBV(CBVa)/post-arterial-CBV(CBVpa) were measured in human brain during breath-hold and visual stimulation. δCBV/CBV was larger during breath-hold (54.9+/-5.8%) than visual stimulation (28.2+/-5.2%), a difference primarily originating from δCBVpa/CBVpa (54.5+/-4.9% vs. 22.2+/-3.8%); δCBVa/CBVa (53+/-6%) and δCBF/CBF (61+/-7%) were comparable in both tasks. During breath-hold, vasodilation distributed proportionally among arterial and post-arterial compartments, whereas, during visual stimulation, relative change in CBVa was greater than that in CBVpa. Our data indicate that the coupling between arterial-CBV and CBF was largely preserved during both tasks (rCBVa=rCBF0.86+/-0.05), while the relationship between total-CBV and CBF was substantially different between breath-hold (rCBV=rCBF0.90+/-0.05) and visual (rCBV=rCBF0.52+/-0.04) stimulation.