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Abstract #1128

Impact of the Mono-Exponential Signal Decay Approximation on the Numerically Predicted Spatial BOLD Specificity for Spin Echo Sequences

Daniel Pflugfelder1, Kaveh Vahedipour1, Kamil Uludag2, Nadim Jon Shah1,3, Tony Stcker1

1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, Jlich, Germany; 2Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany; 3Faculty of Medicine, Department of Neurology, RWTH Aachen University, Aachen, Germany

To increase the spatial specificity of the BOLD signal, a large ratio R of microvascular to macrovascular BOLD signal is desirable. This can be be achieved using spin echo sequences. To simplify the calculation the extravascular BOLD signal (EV) is often approximated by a mono-exponential decay (MEA). To investigate the effect of the MEA we calculated R for multiple B0 and TE without using this approximation. The parameter range for an optimal R was considerable different to the results obtained using the MEA. This is mainly due to an vessel radius dependent delay of the EV which is not reproduced by the MEA.