Abstract #1135

Error Propagation in CMRO2 Derivations Using CBF and BOLD Imaging

Hsiao-Wen Chung¹, Wen Chau Wu

¹Electrical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan

The purpose of this study is therefore to investigate the issues error propagation in CMRO2 estimations under different CNR. Results from our error propagation study suggest that CMRO2 estimations using CBF and BOLD are valid only when the CNR for CBF measurements is sufficiently large, or when the underlying changes in CMRO2 and CBF are sufficiently large as in hypercapnic experiments. Validity of current instantaneous CMRO2 measurements for resting-state brain functional studies is therefore in some doubt.