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Abstract #1198

Reduced BOLD Response in Mice Lacking Nociceptor Specific Sodium Channels (Nav1.7) Indicates Altered Pain Processing

Simone Claudia Bosshard1, Christof Baltes1, Markus Rudin1,2

1Institute for Biomedical Engineering, ETH Zrich, Zurich, Switzerland; 2Institute of Pharmacology and Toxicology, University of Zurich, Zurich, 8057, Switzerland

Electrical stimulation of the forepaws is a widely used stimulation paradigm in functional magnetic resonance imaging (fMRI). We used transgenic mice lacking the voltage-gated sodium channel Nav 1.7 specifically at the nociceptors (Nav1.7R-/-) to study altered pain sensitivity. Nav1.7R-/-, WT littermates and WT animals of our lab were examined using BOLD fMRI. The detected BOLD signal changes of the Nav1.7R-/- animals were significantly reduced as compared to the two WT groups. This is in line with behavioral data reported for these mice. This proves our method to be a valuable tool to non-invasively study pain processing in mice.