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Abstract #1199

BOLD Response and Associated Metabolic Changes in the Rat Barrel Cortex Following Sustained Trigeminal Nerve Stimulation

Nathalie Just1,2, Hanne Frenkel3, Rolf Gruetter3,4

1LIFMET, CIBM, EPFL, Lausanne, Switzerland; 2Department of Radiology, UNIL, Lausanne, Switzerland; 3LIFMET, EPFL, Lausanne, Switzerland; 4Department of Radiology, UNIL and HUG, Lausanne and Geneva, Switzerland

The present study examined the BOLD fMRI response of the rat barrel cortex upon sustained trigeminal nerve stimulation. Moreover, the alterations in the barrel cortex metabolite concentration due to prolonged functional activation were measured using 1H-MRS at 9.4T. The results demonstrate that sustained BOLD responses can be obtained reproducibly in the rat barrel cortex following prolonged trigeminal nerve stimulation. Furthermore, preliminary functional MRS (fMRS) results show changes in several metabolites in the barrel cortex and in particular an increase in lactate levels during barrel cortex activation.