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Abstract #1203

Functional MRI of Cortico-Striato-Thalamal Circuit Using a Novel Flexible Polyimide-Based Microelectrode Array Implanted in Rodent Deep Brain

Pai-Feng Yang1, You-Yin Chen2, Jyh-Horng Chen1, Chen-Tung Yen3

1Electrical Engineering, National Taiwan University, Taipei, Taiwan; 2Electrical Engineering, National Chiao-Tung University, Hsinchu, Taiwan; 3Zoology, National Taiwan University, Taipei, Taiwan

This paper proposes a novel flexible MRI-compatible microelectrode array that leverages the stimulation and recording properties for neuroscience application. We perform functional MRI to investigate the cortico-striato-thalamal circuit with thalamic stimulation. Significant positive BOLD responses were observed in receptive field in upper lip region (S1ULp), barrel field (S1BF) and secondary somatosensory cortex (S2). Negative BOLD responses were revealed in caudate putamen (CPu). We inferred a limbic cortico-striatal loop might exist.