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Abstract #1224

De Novo Buprenorphine Phmri Effects in Conscious Rats Parallels Brain Activation in Humans

Lino Becerra1,2, Pei-Ching Chang1, James Bishop1, Jaymin Upadhyay1, Julie Anderson1, Gautam Pendse1, Smriti Iyengar3, Alexandre Coimbra4, Richard Baumgartner4, Adam Schwarz3, Jeffrey Evelhoch4, Erci Nisenbaum3, Brigitte Robertson5, Thomas Large5, David Bleakman3, Richard Hargreaves4, David Borsook1,2

1Imaging Consortium for Drug Development, McLean Hospital, Belmont, MA, United States; 2A A Martinos Center for Biomed. Imaging, MGH, Harvard Medical School, Charlestown, MA, United States; 3Eli Lilly and Co., Indianapolis, IN, United States; 4Merck and Co, West Point, PA, United States; 5Sepracor Inc., Marlborough, MA, United States

fMRI studies of rodents are confounded by the use of anesthetics, especially for the study of analgesics. Furthermore, there are no studies comparing pharmacological brain effects in humans and rodents of the same analgesics. In this work, we present results of pharmacological MRI (phMRI) of an opioid analgesic (buprenorphine) in conscious rats and compare the brain activations with results obtained in humans. Although brain structure and function differ between humans and rodents, some parallelism does exist and this thesis underpins much pre-clinical research. Translational results as presented here have the potential to bridge pre-clinical with clinical imaging studies.