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Abstract #1225

A FMRI Study to Decipher the Regional Effects of an Intraperitoneal Glucose Dose in the Fasted Rat Model

Kim O'Toole1, Diana Cash1, Steve C R Williams1, Po-Wah So1

1Neuroimaging Department, Institute of Psychiatry, KCL, London, United Kingdom

Glucosensing neurones regulate membrane potential and firing rates in response to ambient glucose levels, and generally located in areas involved in neuroendocrine function, nutrient metabolism and energy homeostasis. Using BOLD-MRI, we have studied the effects of a single intraperitoneal glucose tolerance dose in the brain of a fasted rat model. Glucose induced BOLD-MRI signal increases in various regions of the brain, including the hypothalamus and hippocampus, which are known to contain glucosensing neurones. Thus, BOLD-MRI may be used to a non-invasive tool assess the functional role of nutrients in the brain under different physiological states.