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Abstract #1262

DCE-MRI for the Evaluation of Atherosclerosis in Patients with Exposure to Particulate Matter

Venkatesh Mani1, Simonette T. Sawit2, Claudia Calcagno1, Cynara Maceda2, Colin Moncrieff1, Zahi Adel Fayad1, Jacqueline Moline3, MaryAnn McLaughlin2

1Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Cardiology, Mount Sinai School of Medicine, New York, NY, United States; 3Preventive Medicine, Mount Sinai School of Medicine, New York, NY, United States


Exposure to particulate matter (PM) has been associated with adverse health effects leading to increased morbidity and mortality. Dynamic contrast enhanced (DCE) MRI and peripheral arterial tonometry (PAT) may potentially be used to evaluate differences in atherosclerosis in patients with high and low PM exposure. There was correlation between DCE-MRI measures and endothelial function measured by PAT. Despite NO significant differences between groups in patient characteristics, and vessel wall morphometrics, high exposure group had significantly lower DCE MRI measures. We conclude that DCE-MRI may be used to evaluate differences in atherosclerosis due to different levels of PM exposure.

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