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Abstract #1263

In Vivo Carotid Plaque Magnetic Resonance Imaging Using Quantitative T2* Measurments with USPIO Particles: A Dose-Response Study to Statin Therapy

Andrew James Patterson1, Tjun Y. Tang1, Martin J. Graves1, Simon P. S. Howarth1, Jonathan H. Gillard1

1Radiology, University of Cambridge, Cambridge, England, United Kingdom

Previous studies have reported Ultra-Small Super-Paramagnetic Iron Oxide (USPIO) detected inflammation in carotid atherosclerotic disease using a semi-quantitative analysis technique that involves measuring changes in signal intensity relative to adjacent muscle tissue. In this study an alternative method to detect and quantify changes over-time is presented. The methodology involved making direct quantitative T2* measurements within the atherosclerotic plaque pre- and post- infusion. In a double blinded randomised control trail this study measured a significant difference (p<0.001) with respect to time in USPIO-detected inflammation between patients receiving low-dose and high-dose statin therapy.