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Abstract #1274

Efficient Flow Suppressed MRI Improves Reproducibility of Carotid Atherosclerosis Plaque Burden Measurements

Li Dong1, Jinnan Wang2, Vasily Yarnykh1, Hunter Underhill1, Moni Neradilek3, Thomas Hatsukami1, Chun Yuan1

1University of Washington, Seattle, WA, United States; 2Philips Research North America; 3The Mountain-Whisper-Light Statistics

Previous studies found that a turbo spin-echo based motion-sensitized driven-equilibrium (MSDE) sequence, provides more efficient residual flow signal suppression than the widely used multislice double inversion recovery (mDIR). However, whether this improved flow-suppression can improve reproducibility in atherosclerotic burden measurement is unknown. Bilateral carotid arteries (n=36) from 18 asymptomatic subjects underwent two carotid MRI examinations within 12 days. Compared to mDIR, the MSDE technique had a significantly reduced inter-scan reproducibility for lumen and wall area. For future clinical trials using carotid MRI, improved flow suppression techniques is recommended to monitor progression or regression of atherosclerosis plaque burden.