Jennifer Margaret Jane Richards1, Scott I. Semple2, Calum Gray2, William Wallace3, Roderick TA Chalmers4, Olivier James Garden5, Graham McKillop6, David E. Newby1
1Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; 2Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom; 3Department of Pathology, NHS Lothian, Edinburgh, United Kingdom; 4Vascular Surgical Service, NHS Lothian, Edinburgh, United Kingdom; 5Clinical and Surgical Sciences (Surgery), University of Edinburgh, Edinburgh, United Kingdom; 6Department of Radiology, NHS Lothian, Edinburgh, United Kingdom
The ability to evaluate the biological processes affecting the vessel wall in abdominal aortic aneurysms (AAA) would be beneficial in addition to vessel diameter when evaluating the risk of aneurysm rupture. This is a clinical study (n=9) of the use of Magnetic Resonance Imaging and ultrasmall superparamagnetic particles of iron oxide (USPIO, Sinerem, Guerbet) to detect focal areas of inflammation in the wall of AAA. A reduction in T2* value was observed on T2* weighted imaging before and 24hrs after intravenous administration of 2.6mg/kg Sinerem. Histological examination of operative tissue samples confirmed the presence of iron in the aortic wall.