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Abstract #1279

Preliminary Evaluation of the Short Term Reproducibility of Dynamic Contrast Enhanced (DCE) MRI in Patients with Carotid Atherosclerosis

Claudia Calcagno1, Venkatesh Mani1, Sarayu Ramachandran1, Silvia Aguiar1, John Postley2, Zahi A. Fayad1

1Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Columbia University - College of Physicians and Surgeons

Dynamic contrast enhanced (DCE) MRI can quantify plaque inflammation in atherosclerosis, however its reproducibility is still unknown. We present a preliminary study of the inter-scan reproducibility of the area under the curve (AUC) of contrast agent uptake calculated from DCE-MRI acquisitions in patients with carotid atherosclerosis. We show excellent reproducibility of plaque AUC relative to ipsi-lateral sternocleidomastoideal muscle AUC (ICC respectively 0.972 and 0.755, p<0.05). This preliminary study show encouraging results and suggests that DCE-MRI could be a useful tool for the clinical evaluation of human atherosclerosis and/or in longitudinal clinical drug trials.