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Abstract #1280

Syrian Hamster Model of Postmenopausal Hypercholesterolemia Atherosclerosis and the Development of Plaques as Imaged by High Field MRI

Jens T. Rosenberg1,2, Sara Campbell3, Ihssan Masad, 12, Bahram H. Arjmandi3, Samuel Colles Grant, 12

1CIMAR, The National High Magnetic Field Laboratory, Tallahassee, FL, United States; 2Chemical and Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 3Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, FL, United States

Ovariectomized (ovx) hamsters provide a model of postmenopausal atherosclerosis to investigate plaque formation in cerebral and systemic vasculature. The anti-atherogenic effects of flaxseed were studied by measuring the diameter of vessels using high resolution images acquired at high field (21.1 T). The animals were imaged at three time points: baseline, 4 months and 8 months. Atherosclerotic plaque formations were compared between sham, ovx, and ovx-flaxseed treated animals. No occlusions could be seen in cerebral arteries while differences were identified in the carotids and system circulation.