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Abstract #1281

Ex Vivo MRI Assessment of USPIO Uptake in Aortic Plaque in a Mouse Model of Atherosclerosis at 1

Haiying Tang1, Sherif Fahmy2, Dan Zhou1, Tony Paiva1, Todd Parrish2, Jens H. Jensen3

1Merck Research Laboratories, Rahway, NJ, United States; 2Northwestern University, Chicago, IL, United States; 3New York University School of Medicine, New York, NY, United States

In this study, we present ex vivo MRI assessment of USPIO uptake in aortic plaque in a mouse model of atherosclerosis at 11.7T. The purpose is to evaluate quantitative imaging methods for characterizing USPIO uptake in atherosclerotic plaque. Polymer solution phantoms, cell phantoms, and ex vivo studies were developed to help understand how different signal features are affected by the contrast agent for a variety of pulse sequences. Positive contrast techniques and susceptibility related imaging methods were compared. The goal is to determine which MRI metrics best reflect the contrast agent uptake for the purpose of quantification in living tissues.