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Abstract #1302

Combined Manganese-Enhanced MRI and DTI Methods to Assess Post-Myocardial Infarction Molecular and Structural Remodeling

Benjamin Waghorn1,2, Wen Li3,4, Xin Yu3,4, Tom C.-C. Hu1,2

1Department of Radiology, Medical College of Georgia, Augusta, GA, United States; 2Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology, Atlanta, GA, United States; 3Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 4Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

Intracellular calcium overloading and structural changes are known to occur in the post-myocardial infarction (MI) heart. This study demonstrates the use of combined cardiac T1-mapping manganese-enhanced MRI and DTI in a mouse MI model to examine the relationship between indirect Ca2+ handling and structural modification during the myocardial remodeling process. Decreased Mn2+ uptake was observed for the infracted tissue, as well as the ischemic peri-infarct tissue, with a decrease in diffusivity and an increase in diffusion anisotropy also observed in the infarct hearts. Results from this study could provide a method for monitoring the salvageability of the peri-infarcted zone.