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Abstract #1309

Arterial Spin Labeled MRI Detects Increase in Myocardial Blood Flow with Adenosine

Zungho Zun1, Padmini Varadarajan2, Ramdas G. Pai2, Eric C. Wong3, Krishna S. Nayak1

1Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States; 2Division of Cardiology, Loma Linda University Medical Center, Loma Linda, CA, United States; 3Departments of Radiology and Psychiatry, University of California, San Diego, La Jolla, CA, United States

Myocardial arterial spin labeling (ASL) scans were performed at rest and during adenosine infusion in eleven patients scheduled for CMR. Seven patients were classified as normal based on having no visible perfusion defect on CMR first-pass imaging. In these subjects, there was a statistically significant increase in global myocardial blood flow (MBF) measured during adenosine infusion (3.75 1.06 ml/g/min), compared to at rest (1.09 0.53 ml/g/min). This suggests that myocardial ASL may be capable of capturing clinically relevant increases in MBF with vasodilation.