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Abstract #1316

MRI/MRS Biomarkers for Response Evaluation in Patients with CABG

Zhuoli Zhang1, Shengyong Wu2, Ying Liu3, Savita Puri4, Shara Ramaswamy5, Yi Huan3, Debiao Li1

1Northwestern University, Chicago, IL, United States; 2Tianjin Medical University; 3Fourth Military Medical University; 4University of Rochester Medical Center; 5Florida International University

Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) represents a unique instrument to noninvasively monitor myocardial metabolism in humans. The technique has been used to study the metabolism in myocardium in patients with coronary artery disease (CAD). The measurements permit quantitative estimation of the phosphocreatine (PCr)/adenosine triphosphate (-ATP) ratio which reflects the energetic state of the myocardium. Previous studies investigated the effect of successful coronary artery bypass grafting surgery (CABG) upon left ventricular function. Although residual myocardial viability in patients with CAD and extensive regional asynergy is associated with improved ventricular function after CABG, the relationship between myocardial metabolism and heart function after CABG remains unclear. We hypothesized that cardiac function benefits from high-energy phosphate (HEP) and sought to investigate the relationship between HEP and cardiac function in CAD patients using cine magnetic resonance imaging (cine-MRI) and 31P-MRS.