Vera Schrauwen-Hinderling1, Lena Bilet1, Tineke van de Weijer1, Matthijs Hesselink1, Jan Glatz1, Joachim Wildberger1, Michael Schr2,3, Eline Kooi1, Patrick Schrauwen1
1Maastricht University Medical Center, Maastricht, Netherlands; 2Johns Hopkins University, Baltimore, United States; 3Philips Health Care, Cleveland, United States
Excessive lipid accumulation in the myocardium may predispose to cardiomyopathy. Elevated plasma (free) fatty acids (FA) might be a risk factor herein. Cardiac lipid content was determined by 1H-MRS in healthy men (fasted state). Subsequently, subjects cycled for two hours and rested for three hours, after which cardiac lipid content was measured again. All subjects performed this protocol twice: once fasted and once while ingesting glucose to keep FA low. Cardiac lipid content was elevated after the fasted test day but unchanged when glucose ingestion kept FA low. This suggests that FA are important in determining cardiac lipid content.