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Abstract #1345

Quantification of Pre-Systolic Left Ventricular 4D Blood Flow Organization in Normal and Failing Hearts

Jonatan Eriksson1, Petter Dyverfeldt1, Jan Engvall1, Ann F. Bolger2, Tino Ebbers1, Carl-Johan Carlhll1

1Linkping University and Center for Medical Image Science and Visualization (CMIV), Linkping, Sweden; 2University of California San Francisco, San Francisco, CA, United States

Multidimensional patterns of intracardiac blood flow remain poorly characterized in health and disease. An extended pathline based left ventricular (LV) 4D blood flow quantification approach is presented. Three-directional, three-dimensional cine phase-contrast MRI data was acquired in healthy subjects and patients with idiopathic dilated cardiomyopathy and analyzed for assessment of the pre-systolic LV blood flow organization, in order to evaluate the preparation of different flow components for systolic outflow. Quantification of pre-systolic orientation may reflect an aspect of ventricular systolic efficiency that is impacted by flow-specific organization inside the diastolic ventricle.