Huiling Peng1, Jewell Thomas1, Joseph Mettenburg2, Avi Snyder1, Tammie Benzinger2, David Clifford1, Robert Paul3, Beau Ances4
1Neurology, Washington University in St. Louis, St. Louis, MO, United States; 2Radiology, Washington University in St. Louis, St. Louis, MO, United States; 3Psychology, University of Missouri St. Louis, St. Louis, MO, United States; 4Neurology, Washington University in St. Louis, St. Louis, MO , United States
Hepatitis C virus (HCV) is a frequent co-infection with HIV. Both affect brain function raising the possibility of synergistic interactions. We investigate the relationship between neurological function and white matter integrity using DTI in mono (HIV+) (n=15) vs. co-infected (HIV+/HCV+) (n=13) participants. Regions-of-interest corresponding to the cingulum and genu of the corpus callosum were selected. Co-infected participants were more impaired than mono-infected HIV+ subjects on neuropsychological testing but no significant differences were seen for DTI values. The combination of HIV and HCV co-infection affected measures within the brief neurocognitive screening but not structural neuroimaging measures.