Meeting Banner
Abstract #1570

A Mechanism for Exchange Between Intraaxonal and Extracellular Water: Permeable Nodes of Ranvier

Markus Nilsson1, Hkan Hagsltt2,3, Danielle van Westen2,3, Ronnie Wirestam1, Freddy Sthlberg1,3, Jimmy Ltt1,2

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Center for Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden; 3Department of Diagnostic Radiology, Lund University, Lund, Sweden

The axonal water exchange time was investigated in Monte Carlo simulations using impermeable myelin sheaths, but permeable nodes of Ranvier. The results showed that axonal exchange times on the sub-second were possible for short and intermediate internodal lengths (i.e. length of the myelin sheath) and high nodal permeability. This is of importance for high b-value diffusion MRI when measured with different diffusion times.