Abstract #1570
A
Mechanism for Exchange Between Intraaxonal and Extracellular Water: Permeable
Nodes of Ranvier
Markus
Nilsson1, Hkan Hagsltt2,3, Danielle van Westen2,3,
Ronnie Wirestam1, Freddy Sthlberg1,3, Jimmy Ltt1,2
1Department of Medical Radiation
Physics, Lund University, Lund, Sweden; 2Center for Medical
Imaging and Physiology, Lund University Hospital, Lund, Sweden; 3Department
of Diagnostic Radiology, Lund University, Lund, Sweden
The
axonal water exchange time was investigated in Monte
Carlo simulations using impermeable myelin sheaths, but
permeable nodes of Ranvier. The results showed that axonal exchange times on
the sub-second were possible for short and intermediate internodal lengths
(i.e. length of the myelin sheath) and high nodal permeability. This is of
importance for high b-value diffusion MRI when measured with different
diffusion times.
