Oleg P. Posnansky1, N. J. Shah2,3
1Institute of Neuroscience and Medicine
- 4, Medical Imaging Physics, Forschungszentrum Juelich, GmbH, 52425 Juelich,
Germany; 2Institute of Neuroscience and Medicine - 4, Medical
Imaging Physics , Forschungszentrum Juelich, GmbH , 52425 Juelich, Germany; 3Deparment
of Neurology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen,
Germany
Diffusion
weighted MRI is sensitive to tissue architecture on a micrometer scale.
Determining whether it is possible to infer the specific mechanisms that
underlie changes in the DW-MRI could lead to new diffusion contrasts specific
to particular white-matter degeneration processes. We have developed a
renormalization-group method in order to explore the effects of a large range
of microparameters on apparent-diffusion and applied it to different kind of
brain tissue tessellations. Our approach takes the influence of disorder into
the consideration and it allows quantitative investigation of the sensitivity
of apparent-diffusion to the variations of the dominant set of
microparameters.