Meeting Banner
Abstract #1571

Renormalization Group Method: Influence of Packing Density of Axons on Diffusivity in Enhanced Basser-Sen Model of the Brain White Matter

Oleg P. Posnansky1, N. J. Shah2,3

1Institute of Neuroscience and Medicine - 4, Medical Imaging Physics, Forschungszentrum Juelich, GmbH, 52425 Juelich, Germany; 2Institute of Neuroscience and Medicine - 4, Medical Imaging Physics , Forschungszentrum Juelich, GmbH , 52425 Juelich, Germany; 3Deparment of Neurology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany

Diffusion weighted MRI is sensitive to tissue architecture on a micrometer scale. Determining whether it is possible to infer the specific mechanisms that underlie changes in the DW-MRI could lead to new diffusion contrasts specific to particular white-matter degeneration processes. We have developed a renormalization-group method in order to explore the effects of a large range of microparameters on apparent-diffusion and applied it to different kind of brain tissue tessellations. Our approach takes the influence of disorder into the consideration and it allows quantitative investigation of the sensitivity of apparent-diffusion to the variations of the dominant set of microparameters.