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Abstract #1586

New Quantitative Indices for DWI of the Brain Tissue at High B-Values

Farida Grinberg1, Ezequiel A. Farrher1, Joachim Kaffanke1, Ana-Maria Oros-Peusquens1, N. Jon Jon Shah1,2

1Medical Imaging Physics, Institute of Neuroscience and Medicine 4, Forschungszentrum Juelich GmbH, Juelich, Germany; 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Diffusion MRI permits non-invasive probing of tissue microstructure and function and provides invaluable information in brain diagnostics. Conventional methods, however, are designed to retrieve only the average diffusion characteristics and tend to ignore deviations from simple Gaussian behaviour. Recently, increasing efforts have been dedicated to the development of the advanced approaches capable of capturing more detailed information on the propagation mechanisms. In this work, we report an in vivo diffusion study of the brain based on a detailed analysis of the attenuation patterns. New quantitative indices are suggested as map parameters and their potential use with respect to studies of the brain is discussed.