Ezequiel Alejandro Farrher1, Erasmo Batta1, Yuliya Kupriyanova1, Oleg Posnansky1, Farida Grinberg1, N Jon Shah1,2
1Medical Imaging Physics, Institute of Neuroscience and Medicine 4 , Forschungszentrum Juelich GmbH, Juelich, Germany; 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
Diffusion Tensor Imaging (DTI) provides access to fibre pathways and structural integrity in the white matter and finds important applications in the clinical practice. Many advanced techniques have been recently suggested for the reconstruction of the diffusion orientation distribution function with an enhanced angular resolution (HARDI). Examination of the sensitivity of the proposed diffusion indices to the underlying microstructure requires a development of the model systems with deliberately tailored properties. The aim of this work was to construct artificial phantoms that are characteristic of sufficiently strong diffusion anisotropy and are suitable for the validation of the analytical models.