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Abstract #1641

Evaluating the Uncertainty of DTI Parameters at

Daniel Louis Polders1, Alexander Leemans2, Johannes M. Hoogduin1,3, Jeroen Hendrikse1, Manus Donahue4, Peter R. Luijten1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Netherlands; 4Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom

Diffusion Tensor Imaging data acquired at increased field strength shows increased Signal to Noise Ratio. This work compares the uncertainties of DTI-based metrics when scanning at 1.5 3 and 7T. By scanning the same nine volunteers at each field strength, and applying a wild bootstrap method to calculate the uncertainty of the fitted tensors, it is shown that with increasing SNR, the uncertainties for FA and the primary eigenvector decrease.