Abstract #1645

Dimensional Comparisons of Diffusion Tensor Metrics in Monte Carlo Simulations and Secondary Progressive Multiple Sclerosis

Lingchih Lin¹, Xiaoxu Liu², Jianhui Zhong³

¹Department of Physics and Astronomy , University of Rochester, Rochester, NY, United States; ²Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States; ³Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

The analytical relationships of diffusion tensor (DT) derived parameters were compared to quantify the subtle dependent variation between these metrics. This sensitivity evaluation includes the estimation from Monte Carlo simulations and the implementation in a study of five healthy controls and five patients of secondary progressive multiple sclerosis (SPMS). The fractional anisotropy (FA) was simulated as one-dimensional, two-dimensional, and three-dimensional function and reveal distinct properties in different tissue categories. Both white matter (WM) and gray matter (GM) deterioration were observed with decreasing and increasing FA and changes in radial and axial diffusivities in SPMS.